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A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis

Author:
Núñez González, Luz ElenaUniovi authority; Nybo, Stephen E.; González Sabín, JavierUniovi authority; Pérez, María; Fernández Braña, Alfredo JavierUniovi authority; Salas Fernández, José AntonioUniovi authority; Méndez Fernández, María del CarmenUniovi authority
Publication date:
2012
Publisher version:
http://dx.doi.org/10.1021/jm300234t
Citación:
Journal of medicinal chemistry, 55(12), p. 5813-5825, (2012); doi:10.1021/jm300234t
Descripción física:
p. 5813-5825
URI:
http://hdl.handle.net/10651/9627
ISSN:
0022-2623
Identificador local:

20120901

DOI:
10.1021/jm300234t
Patrocinado por:

This work was supported by grants from the National Institutes of Health (Grant CA091901 to J.R.) and the Spanish Ministry of Science and Innovation (Grants BIO2005-04115 and BIO2008-00269 to C.M. and Grant PET2005-0401 to C.M. and F.M.). M.P. was the recipient of a predoctoral fellowship from the Spanish Ministry of Science and Innovation. L.E.N. was the recipient of Torres-Quevedo Program Funding (Grant PTQ04-3-0487) from the Spanish Ministry of Science and Innovation. S.E.N. was partially supported by a graduate fellowship from the University of Kentucky graduate school.

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