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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia

Author:
Tejedor Vaquero, Juan RamónUniovi authority; Bueno, Clara; Vinyoles, M.; Petazzi, P.; Agraz Doblas, A.; Cobo, I.; Torres Ruiz, R.; Fernández Bayón, GustavoUniovi authority; Fernández Pérez, Raúl; López Tamargo, SaraUniovi authority; Gutiérrez Agüera, F.; Santamarina Ojeda, P.; Ramírez Orellana, M.; Bardini, M.; Cazzaniga, G.; Ballerini, P.; Schneider, P.; Stam, R. W.; Varela, I.; Fernández Fraga, MarioUniovi authority; Fernández Fernández, AgustínUniovi authority; Menéndez, P.
Publication date:
2021
Publisher version:
http://dx.doi.org/10.1172/JCI138833
Citación:
Journal of Clinical Investigation, 131(13) (2021); doi:10.1172/JCI138833
URI:
http://hdl.handle.net/10651/61633
ISSN:
0021-9738
DOI:
10.1172/JCI138833
Patrocinado por:

Financial support for this work was obtained from the European Research Council (CoG-2014-646903 and PoC-2018-811220 to PM), the Spanish Ministry of Economy and Competitiveness (SAF2019-108160-R and SAF2016-76758-R to PM and IV, respectively), the Spanish Association against cancer (AECC-CI-2015 and PROYE18061FERN to CB and MFF), the Fundación Uno entre Cienmil (to PM), the Health Institute Carlos III (ISCIII/FEDER, PI17/01028, PI15/00892, PI18/01527 to CB and AFF/MFF, respectively). We also acknowledge the Plan de Ciencia, Tecnología e Innovación from the Asturias Government cofunding 2018–2022/FEDER (IDI/2018/146 to MFF). JRT and MV are supported by Juan de la Cierva fellowships by the Spanish Ministry of Science and Innovation (FJCI-2015-26965, IJC2018-36825-I, IJCI-2017-3317) and IUOPA-ISPA-FINBA. RTR is supported by a fellowship from the AECC scientific foundation. RFP and PSO are supported by the Severo Ochoa program (BP17-114 and BP17-165, respectively)...

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