Using Factorial Experimental Design to Prepare Size-Tuned Nanovesicles
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American Chemical Society
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The aim of this work was to prepare size-tuned nanovesicles using a modified ethanol injection method (EIM) by applying factorial experimental design. Stable size-tuned nanovesicles (liposomes and niosomes) with controlled sizes and high EE values for hydrophobic compounds (Sudan Red 7B and vitamin D3) were achieved. Equations that were able to predict the mean particle sizes, in the ranges of 55−156 nm for liposomes and 224−362 nm for niosomes with PDI values between 0.032 and 0.378, were obtained. These customized soft nanoparticles could be suitable in food, cosmetic, pharmaceutical, or medical applications, such as diagnosis or therapy
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This work was supported by the Ministerio de Economía y Competitividad (MINECO, Spain), under Grant MINECO-13-CTQ2013-47396-R. This study was also cofinanced by the Consejeria de Educación y Ciencia del Principado de Asturias (ref FC-04-COF-50-MEC , PCTI Asturias 2006-2009, ref EQP06-024, and FC15-GRUPIN14-022). We especially thank Prof. Antonia Salas (University of Oviedo) for her advice with the statistical work.
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