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Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

dc.contributor.authorPérez, María
dc.contributor.authorBaig, Irfan
dc.contributor.authorFernández Braña, Alfredo Javier 
dc.contributor.authorSalas Fernández, José Antonio 
dc.contributor.authorRohr, Jürgen
dc.contributor.authorMéndez Fernández, María del Carmen 
dc.date.accessioned2013-01-30T10:07:28Z
dc.date.available2013-01-30T10:07:28Z
dc.date.issued2008
dc.identifier.citationChemBioChem, 9(14), p. 2295-2304 (2008); doi:10.1002/cbic.200800299spa
dc.identifier.issn1439-4227
dc.identifier.issn1439-7633
dc.identifier.urihttp://hdl.handle.net/10651/8333
dc.description.sponsorshipThis work was supported by grants from the Spanish Ministry of Education and Science to C.M. (BMC2002-03599 and BIO2005-04115), a grant of the US National Institutes of Health (CA 91901) to J.R., and from Red Temática de Investigación Cooperativa de Centros de Cáncer (Ministry of Health, Spain; ISCIII-RETIC RD06/0020/0026). M.P. was the recipient of a predoctoral fellowship of the Spanish Ministry of Science and Technology. We thank the University of Kentucky core laboratories for NMR spectroscopy and mass spectrometry for the usage of their instruments, and the mass spectrometry lab from the Department of Chemistry of U. Nebraska–Lincoln for the high-resolution FAB mass spectra. Pharmamar S.A. is acknowledged for helping us with the antitumor assays.
dc.format.extentp. 2295-2304spa
dc.language.isoeng
dc.relation.ispartofChemBioChemspa
dc.rights© 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
dc.sourceWOKspa
dc.titleGeneration of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesisspa
dc.typejournal article
dc.identifier.local240spa
dc.identifier.doi10.1002/cbic.200800299
dc.relation.projectIDBMC2002-03599
dc.relation.projectIDBIO2005-04115
dc.relation.projectIDCA 91901
dc.relation.projectIDISCIII-RETIC RD06/0020/0026
dc.relation.publisherversionhttp://dx.doi.org/10.1002/cbic.200800299spa


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