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Generation of New Derivatives of the Antitumor Antibiotic Mithramycin by Altering the Glycosylation Pattern through Combinatorial Biosynthesis

Author:
Pérez, María; Baig, Irfan; Fernández Braña, Alfredo JavierUniovi authority; Salas Fernández, José AntonioUniovi authority; Rohr, Jürgen; Méndez Fernández, María del CarmenUniovi authority
Publication date:
2008
Publisher version:
http://dx.doi.org/10.1002/cbic.200800299
Citación:
ChemBioChem, 9(14), p. 2295-2304 (2008); doi:10.1002/cbic.200800299
Descripción física:
p. 2295-2304
URI:
http://hdl.handle.net/10651/8333
ISSN:
1439-4227; 1439-7633
Identificador local:

240

DOI:
10.1002/cbic.200800299
Patrocinado por:

This work was supported by grants from the Spanish Ministry of Education and Science to C.M. (BMC2002-03599 and BIO2005-04115), a grant of the US National Institutes of Health (CA 91901) to J.R., and from Red Temática de Investigación Cooperativa de Centros de Cáncer (Ministry of Health, Spain; ISCIII-RETIC RD06/0020/0026). M.P. was the recipient of a predoctoral fellowship of the Spanish Ministry of Science and Technology. We thank the University of Kentucky core laboratories for NMR spectroscopy and mass spectrometry for the usage of their instruments, and the mass spectrometry lab from the Department of Chemistry of U. Nebraska–Lincoln for the high-resolution FAB mass spectra. Pharmamar S.A. is acknowledged for helping us with the antitumor assays.

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