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Enantioselective desymmetrization of diphenylphosphinamides via (-)-sparteine-mediated ortho-lithiation. synthesis of P-chiral ligands

dc.contributor.authorPopovici, Cristinel
dc.contributor.authorOña Burgos, Pascual
dc.contributor.authorFernández de las Nieves, Ignacio
dc.contributor.authorRoces Fernández, Laura 
dc.contributor.authorGarcía-Granda, Santiago 
dc.contributor.authorIglesias Valdés-Solís, María José
dc.contributor.authorLópez Ortiz, Fernando
dc.date.accessioned2013-01-30T10:06:11Z
dc.date.available2013-01-30T10:06:11Z
dc.date.issued2010
dc.identifier.citationOrganic Letters, 12(3), p. 428-431 (2010); doi:10.1021/ol902545qspa
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/10651/8081
dc.description.abstractAsymmetric ortho-lithiation of N-dialkyl-P,P-diphenylphosphinamides using [n-BuLi·(−)-sparteine] is described as an efficient method for the synthesis of P-chiral ortho-functionalized derivatives in high yields and ee’s from 45 to >99%. The method allows access to new enantiomerically pure P-chiral phosphine and diimine ligands.spa
dc.format.extentp. 428-431spa
dc.language.isoeng
dc.relation.ispartofOrganic Lettersspa
dc.rights(c)American Chemical Society
dc.sourceScopusspa
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-75749117843&partnerID=40&md5=75a7e78d1297e6eb832e61ee3be9af34
dc.titleEnantioselective desymmetrization of diphenylphosphinamides via (-)-sparteine-mediated ortho-lithiation. synthesis of P-chiral ligandsspa
dc.typejournal article
dc.identifier.local20100382spa
dc.identifier.doi10.1021/ol902545q
dc.relation.publisherversionhttp://dx.doi.org/10.1021/ol902545qspa


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