Enantioselective desymmetrization of diphenylphosphinamides via (-)-sparteine-mediated ortho-lithiation. synthesis of P-chiral ligands
Fecha de publicación:
2010
Versión del editor:
Citación:
Organic Letters, 12(3), p. 428-431 (2010); doi:10.1021/ol902545q
Descripción física:
p. 428-431
Resumen:
Asymmetric ortho-lithiation of N-dialkyl-P,P-diphenylphosphinamides using [n-BuLi·(−)-sparteine] is described as an efficient method for the synthesis of P-chiral ortho-functionalized derivatives in high yields and ee’s from 45 to >99%. The method allows access to new enantiomerically pure P-chiral phosphine and diimine ligands.
Asymmetric ortho-lithiation of N-dialkyl-P,P-diphenylphosphinamides using [n-BuLi·(−)-sparteine] is described as an efficient method for the synthesis of P-chiral ortho-functionalized derivatives in high yields and ee’s from 45 to >99%. The method allows access to new enantiomerically pure P-chiral phosphine and diimine ligands.
ISSN:
Identificador local:
20100382
DOI:
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