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The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomielitis in a Spanish population

dc.contributor.authorPérez Is, Laura 
dc.contributor.authorGarcía Ocaña, Marcos 
dc.contributor.authorMontes Hernández, Ángel Hugo 
dc.contributor.authorCartón Sánchez, José Antonio 
dc.contributor.authorÁlvarez Martínez, María Victoria 
dc.contributor.authorMeana Infiesta, Álvaro Enrique 
dc.contributor.authorFierer, Joshua
dc.contributor.authorValle Garay, Eulalia 
dc.contributor.authorAsensi Álvarez, Víctor 
dc.date.accessioned2025-01-14T07:37:38Z
dc.date.available2025-01-14T07:37:38Z
dc.date.issued2019-10-24
dc.identifier.citationPLoS ONE 14(10) (2019); https://doi.org/10.1371/journal. pone.0220022
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/10651/76150
dc.description.abstractOsteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metallo proteinases (MMPs), and coagulation. Lactoferrin (LF), a neutrophil glycoprotein, increases CTSGcatalytic activity and induces inflammation. The aim of this study was to analyze a potential association between a CTSG gene polymorphism (Asn125Ser or N125S, rs45567233), that modifies CTSG activity, and could affect susceptibility to, or outcome of, bacterial osteomyelitisspa
dc.description.sponsorshipThis study was partially funded by a Fondo de Investigaciones Sanitarias (FIS) grant PI16/01999 given to VA. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.spa
dc.language.isoengspa
dc.publisherManal S. Fawzy, Suez Canal University Faculty of Medicine, EGYPTspa
dc.relation.ispartofPLoSONE Volumen 14(10):e0220022spa
dc.rightsCC Reconocimiento 4.0 Internacional
dc.rights© 2019 Pérez-ls et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectcathepsin Gspa
dc.subjectOsteomyelitis
dc.titleThe N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomielitis in a Spanish populationspa
dc.typejournal articlespa
dc.identifier.doi10.1371/journal.pone.0220022
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//PI16%2F01999/ES/Correlación entre metaloproteasas de matriz extracelular, lípidos séricos y cambios en fibrosis hepática en coinfectados VIH-VHC GT1 y 4 tratados con dos regímenes de AAD/ spa
dc.rights.accessRightsopen access
dc.type.hasVersionVoRspa


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