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The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomielitis in a Spanish population
dc.contributor.author | Pérez Is, Laura | |
dc.contributor.author | García Ocaña, Marcos | |
dc.contributor.author | Montes Hernández, Ángel Hugo | |
dc.contributor.author | Cartón Sánchez, José Antonio | |
dc.contributor.author | Álvarez Martínez, María Victoria | |
dc.contributor.author | Meana Infiesta, Álvaro Enrique | |
dc.contributor.author | Fierer, Joshua | |
dc.contributor.author | Valle Garay, Eulalia | |
dc.contributor.author | Asensi Álvarez, Víctor | |
dc.date.accessioned | 2025-01-14T07:37:38Z | |
dc.date.available | 2025-01-14T07:37:38Z | |
dc.date.issued | 2019-10-24 | |
dc.identifier.citation | PLoS ONE 14(10) (2019); https://doi.org/10.1371/journal. pone.0220022 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | https://hdl.handle.net/10651/76150 | |
dc.description.abstract | Osteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metallo proteinases (MMPs), and coagulation. Lactoferrin (LF), a neutrophil glycoprotein, increases CTSGcatalytic activity and induces inflammation. The aim of this study was to analyze a potential association between a CTSG gene polymorphism (Asn125Ser or N125S, rs45567233), that modifies CTSG activity, and could affect susceptibility to, or outcome of, bacterial osteomyelitis | spa |
dc.description.sponsorship | This study was partially funded by a Fondo de Investigaciones Sanitarias (FIS) grant PI16/01999 given to VA. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study. | spa |
dc.language.iso | eng | spa |
dc.publisher | Manal S. Fawzy, Suez Canal University Faculty of Medicine, EGYPT | spa |
dc.relation.ispartof | PLoSONE Volumen 14(10):e0220022 | spa |
dc.rights | CC Reconocimiento 4.0 Internacional | |
dc.rights | © 2019 Pérez-ls et al. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | cathepsin G | spa |
dc.subject | Osteomyelitis | |
dc.title | The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomielitis in a Spanish population | spa |
dc.type | journal article | spa |
dc.identifier.doi | 10.1371/journal.pone.0220022 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//PI16%2F01999/ES/Correlación entre metaloproteasas de matriz extracelular, lípidos séricos y cambios en fibrosis hepática en coinfectados VIH-VHC GT1 y 4 tratados con dos regímenes de AAD/ | spa |
dc.rights.accessRights | open access | |
dc.type.hasVersion | VoR | spa |
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