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The N125S polymorphism in the cathepsin G gene (rs45567233) is associated with susceptibility to osteomielitis in a Spanish population

Autor(es) y otros:
Pérez Is, LauraAutoridad Uniovi; García Ocaña, MarcosAutoridad Uniovi; Montes Hernández, Ángel HugoAutoridad Uniovi; Cartón Sánchez, José AntonioAutoridad Uniovi; Álvarez Martínez, María VictoriaAutoridad Uniovi; Meana Infiesta, Álvaro EnriqueAutoridad Uniovi; Fierer, Joshua; Valle Garay, EulaliaAutoridad Uniovi; Asensi Álvarez, VíctorAutoridad Uniovi
Palabra(s) clave:

cathepsin G

Osteomyelitis

Fecha de publicación:
2019-10-24
Editorial:

Manal S. Fawzy, Suez Canal University Faculty of Medicine, EGYPT

Citación:
PLoS ONE 14(10) (2019); https://doi.org/10.1371/journal. pone.0220022
Resumen:

Osteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metallo proteinases (MMPs), and coagulation. Lactoferrin (LF), a neutrophil glycoprotein, increases CTSGcatalytic activity and induces inflammation. The aim of this study was to analyze a potential association between a CTSG gene polymorphism (Asn125Ser or N125S, rs45567233), that modifies CTSG activity, and could affect susceptibility to, or outcome of, bacterial osteomyelitis

Osteomyelitis is a bone infection, most often caused by Staphylococcus aureus, in which neutrophils play a key role. Cathepsin G (CTSG) is a bactericidal serine protease stored in the neutrophil azurophilic granules. CTSG regulates inflammation, activating matrix metallo proteinases (MMPs), and coagulation. Lactoferrin (LF), a neutrophil glycoprotein, increases CTSGcatalytic activity and induces inflammation. The aim of this study was to analyze a potential association between a CTSG gene polymorphism (Asn125Ser or N125S, rs45567233), that modifies CTSG activity, and could affect susceptibility to, or outcome of, bacterial osteomyelitis

URI:
https://hdl.handle.net/10651/76150
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0220022
Patrocinado por:

This study was partially funded by a Fondo de Investigaciones Sanitarias (FIS) grant PI16/01999 given to VA. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. There was no additional external funding received for this study.

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