Lithium response in bipolar disorder: epigenome-wide dna methylation signatures and epigenetic aging

This work was supported by the Institute of Health Carlos III through projects PI16/00998, PI17/01122, PI18/00805, PI21/00787, PI22/01048 and PI22/00431 co-funded by European Regional Development Fund (ERDF)/European Social Fund “Investing in your future”, the Comissionat per a Universitats i Recerca del DIUE of the Generalitat de Catalunya (AGAUR: 2021SGR01093; 2021SGR00706; 2021SGR01358), the Spanish ‘Ministerio de Ciencia, Innovaci´ on y Universidades’ (PID2021–1277760B-I00, PID2022–139740OA-I00) and La Marat´ o de TV3 (202203–30–31–32). MM, SP, BA, AB, AGP, EJ, AB, PAS, PGP, LGB and JB, thanks the support by CIBER -Consorcio Centro de Investigaci´ on Biomédica en Red, Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (CB07/09/0037, CB07/09/0004 and CB07/09/0020) MM was supported by Horizon 2020 Marie Sklodowska-Curie Individual Fellowship from the European Commission under grant agreement no. 841899 (GRASAD). This article is part of the grant RYC2021–033573-I funded by MICIU/AEI/10.13039/501100011033 and by the European Union NextGenerationEU/PRTR. AGP receives financial support from an educational grant from the Spanish Ministry of Health, Instituto de Salud Carlos III (CM21/00094) and by the European Social Fund Plus (FSE+). EV also thanks the CERCA Programme, and the Departament de Salut de la Generalitat de Catalunya for the PERIS grant SLT006/17/00357 and for the support of the European Union Horizon 2020 research and innovation program (EU.3.1.1. Understanding health, wellbeing, and disease: Grant No 754907 and EU.3.1.3. Treating and managing disease: Grant No 945151).