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Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells

dc.contributor.authorBenedicto, I.
dc.contributor.authorCarmona, R. M.
dc.contributor.authorBarettino, A.
dc.contributor.authorEspinós Estévez, C.
dc.contributor.authorGonzalo, P.
dc.contributor.authorNevado, R. M.
dc.contributor.authorFuente Pérez, M., D. L.
dc.contributor.authorAndrés Manzano, M., J.
dc.contributor.authorGonzález Gómez, C.
dc.contributor.authorRolas, L.
dc.contributor.authorDorado, B.
dc.contributor.authorNourshargh, S.
dc.contributor.authorHamczyk, Magda Rita 
dc.contributor.authorAndrés, V.
dc.date.accessioned2024-10-22T06:06:55Z
dc.date.available2024-10-22T06:06:55Z
dc.date.issued2024
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 121(18) (2024); doi:10.1073/pnas.2400752121
dc.identifier.issn0027-8424
dc.identifier.urihttps://hdl.handle.net/10651/75169
dc.description.sponsorshipR.H. Adams for Tg(Cdh5-cre/ERT2)1Rha mice, J.F.Bentzon for rAAV8-mPCSK9D377Y, and S. Bartlett for English editing. Aorta and mouseicons were made with BioRender.com licensed to V.A. Work supported by grantPID2022-141211OB-I00 funded by MICIU/AEI/10.13039/501100011033 and ERDF/EU. I.B. was supported by Comunidad de Madrid (2017-T1/BMD-5247 and 2021-5A/BMD-20944) with cofunding from European Structural and Investment Fund, RYC2021-033805-I (MICIU/AEI/10.13039/501100011033, European Union NextGenerationEU/PRTR), and PID2022-137111OA-I00 (MICIU/AEI/10.13039/501100011033, ERDF/EU).Salary support to A.B. (BES-2017-079705, MICIU/AEI/10.13039/501100011033,ESF), C.E.-E. (Fundación “la Caixa”, LCF/BQ/DR19/1170012), R.M.N (Ministeriode Educación, Cultura y Deporte, FPU16/05027), and M.R.H. (MICIU, IJC2019-040798-I). CNIC is supported by Instituto de Salud Carlos III (ISCIII), Ministeriode Ciencia, Innovación y Universidades (MICIU), Pro-CNIC Foundation and is aSevero Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). Generation of anti-progerin antibody funded byWellcome Trust (098291/Z/12/Z, 221699/Z/20/Z). Microscopy and Dynamic ImagingUnit-CNIC/ICTS-ReDib supported by ICTS-2018-04-CNIC-16 funded by MICIU/AEI/10.13039/501100011033 and ERDF–A way to make Europe
dc.language.isoeng
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of America
dc.rights© 2024 the Author(s).
dc.rightsCC Reconocimiento – No Comercial –Sin Obra Derivada 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScopus
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85191697477&doi=10.1073%2fpnas.2400752121&partnerID=40&md5=380af3f9dabc8ffa81412e33ed9fca0c
dc.titleExacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
dc.typejournal article
dc.identifier.doi10.1073/pnas.2400752121
dc.relation.projectIDPID2022-141211OB-I00 
dc.relation.projectIDRYC2021-033805-I
dc.relation.projectIDPID2022-137111OA-I00 
dc.relation.projectIDBES-2017-079705 
dc.relation.projectIDFPU16/05027 
dc.relation.publisherversionhttp://dx.doi.org/10.1073/pnas.2400752121
dc.rights.accessRightsopen access
dc.type.hasVersionVoR


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