Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells

R.H. Adams for Tg(Cdh5-cre/ERT2)1Rha mice, J.F.Bentzon for rAAV8-mPCSK9D377Y, and S. Bartlett for English editing. Aorta and mouseicons were made with BioRender.com licensed to V.A. Work supported by grantPID2022-141211OB-I00 funded by MICIU/AEI/10.13039/501100011033 and ERDF/EU. I.B. was supported by Comunidad de Madrid (2017-T1/BMD-5247 and 2021-5A/BMD-20944) with cofunding from European Structural and Investment Fund, RYC2021-033805-I (MICIU/AEI/10.13039/501100011033, European Union NextGenerationEU/PRTR), and PID2022-137111OA-I00 (MICIU/AEI/10.13039/501100011033, ERDF/EU).Salary support to A.B. (BES-2017-079705, MICIU/AEI/10.13039/501100011033,ESF), C.E.-E. (Fundación “la Caixa”, LCF/BQ/DR19/1170012), R.M.N (Ministeriode Educación, Cultura y Deporte, FPU16/05027), and M.R.H. (MICIU, IJC2019-040798-I). CNIC is supported by Instituto de Salud Carlos III (ISCIII), Ministeriode Ciencia, Innovación y Universidades (MICIU), Pro-CNIC Foundation and is aSevero Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). Generation of anti-progerin antibody funded byWellcome Trust (098291/Z/12/Z, 221699/Z/20/Z). Microscopy and Dynamic ImagingUnit-CNIC/ICTS-ReDib supported by ICTS-2018-04-CNIC-16 funded by MICIU/AEI/10.13039/501100011033 and ERDF–A way to make Europe