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CD8+ tumour-infiltrating lymphocytes and tumour microenvironment immune types as biomarkers for Immunotherapy in sinonasal intestinal-type adenocarcinoma

Autor(es) y otros:
García Marín, Rocío; Reda, Sara; Riobello Suárez, CristinaAutoridad Uniovi; Naves Cabal, Virginia; Suárez Fernández, LauraAutoridad Uniovi; Vivanco, Blanca; López Álvarez, Fernando; Llorente Pendás, José LuisAutoridad Uniovi; Hermsen, MarioAutoridad Uniovi
Palabra(s) clave:

Cancer nasosinusal

Fecha de publicación:
2020-04-28
Versión del editor:
https://doi.org/10.3390/vaccines8020202
Citación:
Vaccines, 8(2) (2020); doi:10.3390/vaccines8020202
Resumen:

TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.

TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.

URI:
http://hdl.handle.net/10651/58155
DOI:
10.3390/vaccines8020202
Patrocinado por:

Supported by grants CICPF16008HERM of Fundación AECC, IDI2018/155 Ayudas a Grupos PCTI Principado de Asturias, and CB16/12/00390 from the Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Plan Nacional de I+D+I 2013-2016 of the Plan Estatal cofinanced by the FEDER Funding Program from the European Union.

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