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TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
dc.contributor.author | García Mayea, Yoelsis | |
dc.contributor.author | Mir, Cirstina | |
dc.contributor.author | Carballo, Laia | |
dc.contributor.author | Castellvi, Josep | |
dc.contributor.author | Temprana Salvador, Jordi | |
dc.contributor.author | Lorente, Juan | |
dc.contributor.author | Benavente, Sergi | |
dc.contributor.author | García Pedrero, Juana María | |
dc.contributor.author | Allonca Campa, Eva | |
dc.contributor.author | Rodrigo Tapia, Juan Pablo | |
dc.contributor.author | Lleonart, Matilde E. | |
dc.date.accessioned | 2021-03-16T10:43:43Z | |
dc.date.available | 2021-03-16T10:43:43Z | |
dc.date.issued | 2020-11-05 | |
dc.identifier.citation | Cancers, 12(11) (2020); doi:10.3390/cancers12113269 | |
dc.identifier.uri | http://hdl.handle.net/10651/58154 | |
dc.description.abstract | Therapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin resistance. Through this study, we identified for the first time tetraspanin-1 (TSPAN1) as an important protein involved in the development, progression and chemoresistance of HNSCC tumors. | spa |
dc.description.sponsorship | This work was supported by grants from the Instituto de Salud Carlos III (ISCIII): PI15/01262 (M.E.LL.) PI19/00560 (J.M.G.-P.) and CP03/00101 (M.E.L.), CIBERONC (CB16/12/00390 to J.P.R.), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155 to J.P.R.), co-financed by the European Regional Fund (ERDF) and AECC (Spanish Association of Cancer Research) Founding Ref. GC16173720CARR (M.E.L.). Y.G.-M. and C.M. were granted by the VHIR and iP-FIS (ISCIII) fellowships respectively. | spa |
dc.language.iso | eng | spa |
dc.publisher | MDPI | spa |
dc.relation.ispartof | Cancers,12(11) | spa |
dc.rights | CC Reconocimiento 4.0 Internacional | |
dc.rights | © 2020 García Mayea et al. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Cáncer de cabeza y cuello | spa |
dc.title | TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance | spa |
dc.type | journal article | spa |
dc.identifier.doi | 10.3390/cancers12113269 | |
dc.relation.projectID | ISCIII/PI19/00560 | |
dc.relation.projectID | CB16/12/00390 | |
dc.relation.projectID | IDI2018/155 | |
dc.relation.publisherversion | https://doi.org/10.3390/cancers12113269 | |
dc.rights.accessRights | open access | spa |
dc.type.hasVersion | VoR |
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