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TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance

dc.contributor.authorGarcía Mayea, Yoelsis
dc.contributor.authorMir, Cirstina
dc.contributor.authorCarballo, Laia
dc.contributor.authorCastellvi, Josep
dc.contributor.authorTemprana Salvador, Jordi
dc.contributor.authorLorente, Juan
dc.contributor.authorBenavente, Sergi
dc.contributor.authorGarcía Pedrero, Juana María 
dc.contributor.authorAllonca Campa, Eva 
dc.contributor.authorRodrigo Tapia, Juan Pablo 
dc.contributor.authorLleonart, Matilde E.
dc.date.accessioned2021-03-16T10:43:43Z
dc.date.available2021-03-16T10:43:43Z
dc.date.issued2020-11-05
dc.identifier.citationCancers, 12(11) (2020); doi:10.3390/cancers12113269
dc.identifier.urihttp://hdl.handle.net/10651/58154
dc.description.abstractTherapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin resistance. Through this study, we identified for the first time tetraspanin-1 (TSPAN1) as an important protein involved in the development, progression and chemoresistance of HNSCC tumors.spa
dc.description.sponsorshipThis work was supported by grants from the Instituto de Salud Carlos III (ISCIII): PI15/01262 (M.E.LL.) PI19/00560 (J.M.G.-P.) and CP03/00101 (M.E.L.), CIBERONC (CB16/12/00390 to J.P.R.), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155 to J.P.R.), co-financed by the European Regional Fund (ERDF) and AECC (Spanish Association of Cancer Research) Founding Ref. GC16173720CARR (M.E.L.). Y.G.-M. and C.M. were granted by the VHIR and iP-FIS (ISCIII) fellowships respectively.spa
dc.language.isoengspa
dc.publisherMDPIspa
dc.relation.ispartofCancers,12(11)spa
dc.rightsCC Reconocimiento 4.0 Internacional
dc.rights© 2020 García Mayea et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCáncer de cabeza y cuellospa
dc.titleTSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistancespa
dc.typejournal articlespa
dc.identifier.doi10.3390/cancers12113269
dc.relation.projectIDISCIII/PI19/00560
dc.relation.projectIDCB16/12/00390
dc.relation.projectIDIDI2018/155
dc.relation.publisherversionhttps://doi.org/10.3390/cancers12113269
dc.rights.accessRightsopen accessspa
dc.type.hasVersionVoR


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