Dynamics of uS19 C-Terminal Tail during the Translation Elongation Cycle in Human Ribosomes

This work was supported by the Novartis Research Foundation (J.A.C.), the Swiss National Science Foundation grant 31003A_182314 (J.A.C.), the SNFNCCR RNA & Disease (J.A.C.), the Synapsis Foundation 2017 CDA 01 (V.B.), CNRS, Association pour la Recherche sur le Cancer (ARC), Institut National du Cancer (INCa), Ligue Nationale Contre le Cancer (Ligue), Agence National pour la Recherche (ANR), the Fondation pour la Recherche Médicale (FRM), the French Infrastructure for Integrated Structural Biology (FRISBI; ANR-10-INSB-05-01), and Instruct-ERIC. We thank C. Genoud for EM support, N. Thomä and his group for helpful discussions, Dr. López-Otín and Dr. Víctor Quesada for providing uS19 mutant cell lines, and S. Chakrabarti and J. Nörpel for critically reading the manuscript.