New sipanmycin analogues generated by combinatorial biosynthesis and mutasynthesis approaches relying on the substrate flexibility of key enzymes in the biosynthetic pathway
Fecha de publicación:
2020
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Citación:
Applied and Environmental Microbiology, 86(3), p. e02453- (2020); doi:10.1128/AEM.02453-19
Descripción física:
p. e02453-
ISSN:
DOI:
Patrocinado por:
This research was supported by grants from the Spanish Ministry of Economy and Competitiveness (grant BIO2015-64161-R to J.A.S.) and MCIU/AEI/FEDER, UE (grant RTI2018- 093562-B-I00 to J.A.S and C.O). The NMR spectrometer used in this work was purchased via a grant for scientific and technological infrastructure from the Ministerio de Ciencia e Innovación (grant PCT-010000-2010-4).
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