Enzymatic Preparation of Novel Aminoalkylpyridines usingLipases in Organic Solvents

Abstract

A wide range of novel, enantiomericallypure 4-chloroACHTUNGTRENNUNG(amino)pyridine derivatives has beensynthesised through a chemoenzymatic approach,Candida antarctica lipase B (CAL-B) and Pseudomo-nas cepacia lipase (PSL) being found to be excellentbiocatalysts for the preparation of new and interest-ing amines and amides in enantiomerically pureform through enzymatic aminolysis reactions. Astudy of the enzymatic reactivity of CAL-B and PSLhas been done in the resolution of a library of aminestructures in an attempt to rationalise the experimen-tal results obtained in their enzymatic kinetic resolu-tion mediated by lipases