Enzymatic Preparation of Novel Aminoalkylpyridines usingLipases in Organic Solvents
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A wide range of novel, enantiomericallypure 4-chloroACHTUNGTRENNUNG(amino)pyridine derivatives has beensynthesised through a chemoenzymatic approach,Candida antarctica lipase B (CAL-B) and Pseudomo-nas cepacia lipase (PSL) being found to be excellentbiocatalysts for the preparation of new and interest-ing amines and amides in enantiomerically pureform through enzymatic aminolysis reactions. Astudy of the enzymatic reactivity of CAL-B and PSLhas been done in the resolution of a library of aminestructures in an attempt to rationalise the experimen-tal results obtained in their enzymatic kinetic resolu-tion mediated by lipases
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Financial support of this work by the European Project EU-04-LSHB-2003–503017 and the Principado de Asturias (IB-05–109) is gratefully acknowledged. V. G.-F. and E. B thankMinisterio de Educación y Ciencia for a personal grant (Juande la Cierva Program), and a pre-doctoral fellowship respec-tively.
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