Study of the Chemoselectivity in the Aminolysis Reaction ofMethyl Acrylate Catalysed by Lipase B from Candida antarctica

Abstract

The aminolysis reaction of methyl acrylate(MA) with N,N-dimethyl-1,3-propanediamine(DMAPA) in organic solvents has been optimised us-ing lipase B from Candida antarctica (CAL-B) as bio-catalyst. A kinetic study about the influence of the re-actant concentrations, organic solvent, temperatureand enzyme form has been developed focused onminimising the formatio n of the Michael additionproducts. The economic efficiency of this processhas been finally investigated by reusing the enzymein the best reaction conditions, thereby observing nosignificant loss of activity after three reaction cycles.