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Study of the Chemoselectivity in the Aminolysis Reaction ofMethyl Acrylate Catalysed by Lipase B from Candida antarctica

Author:
Torre González, OliverUniovi authority; Gotor Fernández, VicenteUniovi authority; Alfonso, Ignacio; García Alles, Luis Fernando; Gotor Santamaría, Vicente MiguelUniovi authority
Publication date:
2005
Publisher version:
https://doi.org/10.1002/adsc.200505025
Citación:
Advanced Synthesis and Catalysis, 347(7-8), p. 1007-1014 (2005); doi:10.1002/adsc.200505025
Descripción física:
p. 1007-1014
Abstract:

The aminolysis reaction of methyl acrylate(MA) with N,N-dimethyl-1,3-propanediamine(DMAPA) in organic solvents has been optimised us-ing lipase B from Candida antarctica (CAL-B) as bio-catalyst. A kinetic study about the influence of the re-actant concentrations, organic solvent, temperatureand enzyme form has been developed focused onminimising the formatio n of the Michael additionproducts. The economic efficiency of this processhas been finally investigated by reusing the enzymein the best reaction conditions, thereby observing nosignificant loss of activity after three reaction cycles.

The aminolysis reaction of methyl acrylate(MA) with N,N-dimethyl-1,3-propanediamine(DMAPA) in organic solvents has been optimised us-ing lipase B from Candida antarctica (CAL-B) as bio-catalyst. A kinetic study about the influence of the re-actant concentrations, organic solvent, temperatureand enzyme form has been developed focused onminimising the formatio n of the Michael additionproducts. The economic efficiency of this processhas been finally investigated by reusing the enzymein the best reaction conditions, thereby observing nosignificant loss of activity after three reaction cycles.

URI:
http://hdl.handle.net/10651/54876
ISSN:
1615-4150
DOI:
10.1002/adsc.200505025
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