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A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model

dc.contributor.advisorLombó Brugos, Felipe 
dc.contributor.authorFernández Fernández, Javier 
dc.contributor.authorMoreno, F. J.
dc.contributor.authorOlano, Agustín
dc.contributor.authorClemente, Alfonso
dc.contributor.authorVillar Granja, Claudio Jesús 
dc.date.accessioned2018-09-07T07:24:38Z
dc.date.available2018-09-07T07:24:38Z
dc.date.issued2018
dc.identifier.citationFrontiers in Microbiology, 9, p. 2004- (2018); doi: 10.3389/fmicb.2018.02004
dc.identifier.urihttp://hdl.handle.net/10651/48490
dc.descriptionDataset disponible en la versión del editor.
dc.descriptionAbstract: Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model (Rattus norvegicus F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as Bifidobacterium. Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC.
dc.description.sponsorshipThis work was funded by the research project grants RTC-2014-1525 from MINECO (Spanish Ministry of Economy, Industry and Competitiveness), AGL2017-84614-C2-1-R from MINECO, and AGR2011-7626 from Junta de Andalucía (Spain).
dc.format.extentp. 2004-spa
dc.language.isoengspa
dc.relation.ispartofFrontiers in Microbiology, 9spa
dc.rights© 2018 Felipe Lombo et al.
dc.rightsCC Reconocimiento - No comercial - Sin obras derivadas 4.0 Internacional
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleA galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal modeleng
dc.typeinfo:eu-repo/semantics/articlespa
dc.identifier.doi10.3389/fmicb.2018.02004
dc.relation.projectIDMINECO/RTC-2014-1525
dc.relation.projectIDMINECO/AGL2017-84614-C2-1-R
dc.relation.publisherversionhttps://doi.org/10.3389/fmicb.2018.02004


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© 2018 Felipe Lombo et al.
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