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A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model
| dc.contributor.advisor | Lombó Brugos, Felipe | |
| dc.contributor.author | Fernández Fernández, Javier | |
| dc.contributor.author | Moreno, F. J. | |
| dc.contributor.author | Olano, Agustín | |
| dc.contributor.author | Clemente, Alfonso | |
| dc.contributor.author | Villar Granja, Claudio Jesús | |
| dc.date.accessioned | 2018-09-07T07:24:38Z | |
| dc.date.available | 2018-09-07T07:24:38Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Frontiers in Microbiology, 9, p. 2004- (2018); doi: 10.3389/fmicb.2018.02004 | |
| dc.identifier.uri | http://hdl.handle.net/10651/48490 | |
| dc.description | Dataset disponible en la versión del editor. | |
| dc.description | Abstract: Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model (Rattus norvegicus F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as Bifidobacterium. Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC. | |
| dc.description.sponsorship | This work was funded by the research project grants RTC-2014-1525 from MINECO (Spanish Ministry of Economy, Industry and Competitiveness), AGL2017-84614-C2-1-R from MINECO, and AGR2011-7626 from Junta de Andalucía (Spain). | |
| dc.format.extent | p. 2004- | spa |
| dc.language.iso | eng | spa |
| dc.relation.ispartof | Frontiers in Microbiology, 9 | spa |
| dc.rights | © 2018 Felipe Lombo et al. | |
| dc.rights | CC Reconocimiento 4.0 Internacional | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | A galacto-oligosaccharides preparation derived from lactulose protects against colorectal cancer development in an animal model | eng |
| dc.type | journal article | spa |
| dc.identifier.doi | 10.3389/fmicb.2018.02004 | |
| dc.relation.projectID | MINECO/RTC-2014-1525 | |
| dc.relation.projectID | MINECO/AGL2017-84614-C2-1-R | |
| dc.relation.publisherversion | https://doi.org/10.3389/fmicb.2018.02004 | |
| dc.rights.accessRights | open access |
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