Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme A stimulates autophagy and prolongs lifespan

We thank Drs. Jef D. Boeke, Daniel Klionsky, and Gunther Daum for providing antibodies. We are also grateful for strains provided by Dr. Boeke. We thank Harald Hofbauer for support with quantitative PCR; and Lydia Opriessnig, Christian Pendl, and Birgit Michelitsch for assistance. This work was supported by the Austrian Science Fund FWF (grants T414-B09 and V235-B09 to S.B.; grants LIPOTOX, I1000, P23490-B12, and P24381-B20 to F.M.). T.E. is recipient of an APART fellowship of the Austrian Academy of Sciences at the Institute of Molecular Biosciences, University of Graz. This work was also supported by grants to G.K. from the Ligue Contre le Cancer (Équipe Labelisée), Agence National de la Recherche (ANR), Association Pour la Recherche sur le Cancer (ARC), Cancéropôle Ile-de-France; AXA Chair for Longevity Research, Institut National du Cancer (INCa), Fondation Bettencourt-Schueller, Fondation de France, Fondation pour la Recherche Médicale (FRM), the European Commission (ArtForce), the European Research Council (ERC), the LabEx Immuno-Oncology, the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), the SIRIC Cancer Research and Personalized Medicine (CARPEM), and the Paris Alliance of Cancer Research Institutes (PACRI).