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Affinity of aptamers binding 33-mer gliadin peptide and gluten proteins: Influence of immobilization and labeling tags

Author:
Amaya González, SoniaUniovi authority; López López, Laura; Miranda Castro, RebecaUniovi authority; Santos Álvarez, Noemí de losUniovi authority; Miranda Ordieres, Arturo JoséUniovi authority; Lobo Castañón, María JesúsUniovi authority
Subject:

Aptamer

Gluten

Binding constant

Publication date:
2015
Editorial:

Elsevier

Publisher version:
http://dx.doi.org/10.1016/j.aca.2015.02.053
Citación:
Analytica Chimica Acta, 873, p. 63-70 (2015); doi:10.1016/j.aca.2015.02.053
Descripción física:
p. 63-70
Abstract:

Aptamers are starting to increase the reagents tool box to develop more sensitive and reliable methods for food allergens. In most of these assays, aptamers have to be modified for detection and/or immobilization purposes. To take full advantage of their affinity, which decisively influence the detectability, these modifications must be faced rationally. In this work, a recently developed aptamer for an immunotoxic peptide of gliadin associated to celiac disease is used in different configurations and modified with various markers and anchored groups to evaluate the influence of such modifications on the real affinity...

Aptamers are starting to increase the reagents tool box to develop more sensitive and reliable methods for food allergens. In most of these assays, aptamers have to be modified for detection and/or immobilization purposes. To take full advantage of their affinity, which decisively influence the detectability, these modifications must be faced rationally. In this work, a recently developed aptamer for an immunotoxic peptide of gliadin associated to celiac disease is used in different configurations and modified with various markers and anchored groups to evaluate the influence of such modifications on the real affinity...

URI:
http://hdl.handle.net/10651/32546
ISSN:
0003-2670; 1873-4324
DOI:
10.1016/j.aca.2015.02.053
Patrocinado por:

This work was financed by Spanish Government Project CTQ2012-31157, and the European Regional Development Fund.

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