Asymmetric deprotonation-substitution of n-pop-benzylamines using [rli/(-)-sparteine]. Enantioselective sequential reactions and synthesis of n-heterocycles
Publication date:
2008Publisher version:
http://dx.doi.org/10.1021/ol801027pCitación:
Organic Letters, 10(15), p. 3195-3198 (2008); doi:10.1021/ol801027pDescripción física:
p. 3195-3198Abstract:
Pop-directed asymmetric deprotonation of benzylic amines using [n-BuLi/(−)-sparteine] provides an efficient method for the synthesis of chiral NCα and NCα,α′ derivatives with total selectivity with respect to competing allylic and ortho lithiation. The method described herein offers a straightforward route of accessing chiral N-Pop-protected nitrogen heterocycles.
ISSN:
1523-7060Identificador local:
20080090
DOI:
10.1021/ol801027pCollections
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