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Flow cytometric analysis of nuclear DNA content in oral leukoplakia.

Autor(es) y otros:
Seoane, Juan Manuel; Bascones, Antonio; Asenjo, José Antonio; García-Pola Vallejo, María JoséAutoridad Uniovi; Varela-Centelles, Pablo
Palabra(s) clave:

oral leukoplakia, ploidy, flow cytometry

Fecha de publicación:
1998-04
Versión del editor:
https://doi.org/10.1046/j.1365-2273.1998.00116.x
Citación:
Clinical Otolaryngology & Alliance Sciences, 23(2), p. 136-40 (1998); doi:10.1046/j.1365-2273.1998.00116.x
Descripción física:
p. 136-140
Resumen:

DNA ploidy has been studied in 20 para.n!embedded specimens of oral leukoplakia and in 09 specimens of oral leukoplakia that have undergone malignant transformation after a 4!year observation period[ Three out of 20 specimens "8[6)# showed an aneuploid DNA pattern\ with DNA indices of 0[06\ 0[17 and 0[21[ It was not possible to establish a statistically signi_cant di}erence of DNA ploidy related to the presence or absence of dysplasia[ One out of the 09 oral leukoplakias that underwent malignant transformations had a multiploid pattern with DNA indices of 0[33 and 1[26[ In this study the DNA index has not proved to be of value in the identi_cation of dysplastic leukoplakia among the non!dysplastic ones[

DNA ploidy has been studied in 20 para.n!embedded specimens of oral leukoplakia and in 09 specimens of oral leukoplakia that have undergone malignant transformation after a 4!year observation period[ Three out of 20 specimens "8[6)# showed an aneuploid DNA pattern\ with DNA indices of 0[06\ 0[17 and 0[21[ It was not possible to establish a statistically signi_cant di}erence of DNA ploidy related to the presence or absence of dysplasia[ One out of the 09 oral leukoplakias that underwent malignant transformations had a multiploid pattern with DNA indices of 0[33 and 1[26[ In this study the DNA index has not proved to be of value in the identi_cation of dysplastic leukoplakia among the non!dysplastic ones[

URI:
https://hdl.handle.net/10651/76237
ISSN:
1749-4478
DOI:
10.1046/j.1365-2273.1998.00116.x
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