RUO Principal

Repositorio Institucional de la Universidad de Oviedo

Ver ítem 
  •   RUO Principal
  • Producción Bibliográfica de UniOvi: RECOPILA
  • Artículos
  • Ver ítem
  •   RUO Principal
  • Producción Bibliográfica de UniOvi: RECOPILA
  • Artículos
  • Ver ítem
    • español
    • English
JavaScript is disabled for your browser. Some features of this site may not work without it.

Listar

Todo RUOComunidades y ColeccionesPor fecha de publicaciónAutoresTítulosMateriasxmlui.ArtifactBrowser.Navigation.browse_issnPerfil de autorEsta colecciónPor fecha de publicaciónAutoresTítulosMateriasxmlui.ArtifactBrowser.Navigation.browse_issn

Mi cuenta

AccederRegistro

Estadísticas

Ver Estadísticas de uso

AÑADIDO RECIENTEMENTE

Novedades
Repositorio
Cómo publicar
Recursos
FAQs

Reduction of Cisplatin-Induced Nephrotoxicity in Vivo by Selenomethionine: The Effect on Cisplatin-DNA Adducts

Autor(es) y otros:
García Sar, DanielAutoridad Uniovi; Montes Bayón, MaríaAutoridad Uniovi; Blanco González, ElisaAutoridad Uniovi; Sierra Zapico, Luisa MaríaAutoridad Uniovi; Sanz Medel, AlfredoAutoridad Uniovi
Fecha de publicación:
2011
Versión del editor:
http://dx.doi.org/10.1021/tx200085n
Citación:
Chemical research in toxicology, 24(6), p. 896-904 (2011); doi:10.1021/tx200085n
Descripción física:
p. 896-904
Resumen:

Cisplatin is one of the most effective chemotherapeutic agents, although its clinical use is limited by severe renal toxicity. This toxicity seems to be related to the accumulation of the drug in kidney tissues, leading to renal failure. For this reason, several compounds have been evaluated to ameliorate the nephrotoxicity induced by cisplatin. In the present investigation, we report the effect of the oral administration of selenomethionine before intraperitoneal cisplatin treatment. The preadministration of this Se species has been shown to have an important effect in reducing renal damage induced by cisplatin by increasing the excreted urea and improving creatinine clearance. Quantification of the level of DNA–cisplatin adducts in kidney and liver tissues was carried out by postcolumn isotope dilution analysis using liquid chromatography-inductively coupled plasma (LC-ICP-MS) as speciation set up. The level of DNA–cisplatin adducts in rats given Se-methionine in the drinking water before cisplatin administration was considerably lower in kidney tissues with respect to the animals drinking only water. Such effects were not observed in liver tissue. Initial speciation studies of Pt and Se conducted in kidney tissues of exposed animals by HPLC-ICP-MS have revealed the presence of cisplatin as part of a complex with Se-methionine, which can be eventually excreted into urine. This Pt–Se complex could explain the observed reduction of the kidney damage in Se-methionine-treated animals.

Cisplatin is one of the most effective chemotherapeutic agents, although its clinical use is limited by severe renal toxicity. This toxicity seems to be related to the accumulation of the drug in kidney tissues, leading to renal failure. For this reason, several compounds have been evaluated to ameliorate the nephrotoxicity induced by cisplatin. In the present investigation, we report the effect of the oral administration of selenomethionine before intraperitoneal cisplatin treatment. The preadministration of this Se species has been shown to have an important effect in reducing renal damage induced by cisplatin by increasing the excreted urea and improving creatinine clearance. Quantification of the level of DNA–cisplatin adducts in kidney and liver tissues was carried out by postcolumn isotope dilution analysis using liquid chromatography-inductively coupled plasma (LC-ICP-MS) as speciation set up. The level of DNA–cisplatin adducts in rats given Se-methionine in the drinking water before cisplatin administration was considerably lower in kidney tissues with respect to the animals drinking only water. Such effects were not observed in liver tissue. Initial speciation studies of Pt and Se conducted in kidney tissues of exposed animals by HPLC-ICP-MS have revealed the presence of cisplatin as part of a complex with Se-methionine, which can be eventually excreted into urine. This Pt–Se complex could explain the observed reduction of the kidney damage in Se-methionine-treated animals.

URI:
http://hdl.handle.net/10651/7318
ISSN:
0893-228X
Identificador local:

20111424

DOI:
10.1021/tx200085n
Patrocinado por:

We are thankful for the financial support of the project from MICIIN reference CTQ2007-60206/BQU and D. G. Sar for his fellowship from MICIIN reference FPU-AP06-04208.

Colecciones
  • Artículos [37534]
Ficheros en el ítem
Métricas
Compartir
Exportar a Mendeley
Estadísticas de uso
Estadísticas de uso
Metadatos
Mostrar el registro completo del ítem
Página principal Uniovi

Biblioteca

Contacto

Facebook Universidad de OviedoTwitter Universidad de Oviedo
El contenido del Repositorio, a menos que se indique lo contrario, está protegido con una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Creative Commons Image