Matrix metalloprotease 8-dependent extracellular matrix cleavage at the blood-CSF barrier contributes to lethality during systemic inflammatory diseases
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20120909
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This work was supported by the agency for the Innovation by Science and Technology in Flanders,the Research Council of Ghent University, the Research Foundation Flanders, and the Interuniversity Attraction Poles Program of the Belgian Science Policy (IAP-VI-18). Work at the laboratory of C.L.-O. was supported by grants from the Ministry of Education and Science of Spain,the M. Botín Foundation,the Lilly Foundation,and the European Union.Work at the laboratory of P.M.was supported by grants fromthe Dormeur Foundation. We thank Amin Bredan for editing the manuscript, British Biotech for providing BB-94, Dr. K. Devreese for coagulation tests, Dr. C. Gue´rin for suggestions concerning the confocal studies, Dr.W. Waelput for help with the histopathology, and Sophie Steel and for excellent technical assistance.
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