Determination of endogenous trace elements in extracellular vesicles secreted by an in vitro model of human retinal pigment epithelium under oxidative stress conditions using icp-ms

This work was financially supported through projects PID2019- 107838RB-I00/Agencia Estatal de Investigación (AEI)/10.13039/501100011033) and the PCTI Program of the Government of the Principality of Asturias and FEDER Program of the European Union (No. AYUD/2021/51289). J. Martínez-García acknowledges the “Severo Ochoa” Program Grant with Ref. BP21-041 (Principality of Asturias, Spain). Authors want to acknowledge C. Derrick Quarles Jr. for his support with the microFAST Single Cell system, and the technical support provided by Servicios Científico-Técnicos of the University of Oviedo – Mass Spectrometry and Electron Microscopy Units. The Instituto Oftalmológico Fernández-Vega and Fundación de Investigación Oftalmológica acknowledge financial support from the Fundación Rafael del Pino (http://www.frdelpino.es), through the “Cátedra Rafael del Pino” and from IDE/2019/000289 project of “Instituto de Desarrollo Económico del Principado de Asturias” (IDEPA) of Gobierno del Principado de Asturias and FEDER.