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C.L-O. is supported by grants from the European Research Council (ERC Advanced Grant, DeAge), Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III, and La Caixa Foundation (HR17-00221). The Instituto Universitario de Oncología is supported by Fundación Bancaria Caja de Ahorros de Asturias. M.B. is funded by Agencia Estatal de Investigación (AEI/MCI/10.13039/501100011033, project RETOS SAF2017-82623-R), cofunded by European Regional Development Fund, “A way of making Europe”; Comunidad de Madrid with the Sinergy Project COVIDPREclinicalMODels-CM and the ERC under the European Union's Horizon 2020 research and innovation programme (grant 882385) through the project ERC-AvG SHELTERINS. The CNIO, certified as Severo Ochoa Centre of Excellence by AEI/MCI/10.13039/501100011033, is supported by the Spanish Government through the Instituto de Salud Carlos III (...)