Biosynthesis of Largimycins in Streptomyces argillaceus Involves
Transient β‑Alkylation and Cryptic Halogenation Steps
Unprecedented in the Leinamycin Family

Becerril García, Adriana; Pérez Victoria, I.; Martín, J. M.; Reyes, F.; Salas Fernández, José Antonio; Méndez Fernández, María del Carmen

doi:10.1021/acschembio.2c00416

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Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β‑Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family

dc.contributor.author	Becerril García, Adriana
dc.contributor.author	Pérez Victoria, I.
dc.contributor.author	Martín, J. M.
dc.contributor.author	Reyes, F.
dc.contributor.author	Salas Fernández, José Antonio
dc.contributor.author	Méndez Fernández, María del Carmen
dc.date.accessioned	2023-03-02T09:29:46Z
dc.date.available	2023-03-02T09:29:46Z
dc.date.issued	2022
dc.identifier.citation	ACS Chemical Biology, 17(8), p. 2320-2331 (2022); doi:10.1021/acschembio.2c00416
dc.identifier.issn	1554-8929
dc.identifier.uri	http://hdl.handle.net/10651/66659
dc.description.sponsorship	his work was supported by grants from the Spanish Ministry of Economy and Competitiveness, MINECO (Grants BIO2014-56752-R, BIO2017-82462-R, and PID2020- 113062RB-100 to C.M.), by the grant “Apoyo a grupos de excelencia”, Principado de Asturias-FEDER (FC-15-GRU- PIN14-014), and by the grant PAPI-20-GR-2010-0019 from Universidad de Oviedo. A.B. was recipient of a predoctoral fellowship from MINECO (FPU13/00831).
dc.format.extent	p. 2320-2331
dc.language.iso	eng
dc.relation.ispartof	ACS Chemical Biology
dc.rights	© 2022 The Authors. Published by American Chemical Society
dc.rights	CC Reconocimiento 4.0 Internacional
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.source	Scopus
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135207890&doi=10.1021%2facschembio.2c00416&partnerID=40&md5=4908ad4520e186398a2580185e1c22ae
dc.title	Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β‑Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family
dc.type	journal article
dc.identifier.doi	10.1021/acschembio.2c00416
dc.local.notes	OA ATUO22
dc.relation.projectID	MINECO/BIO2014-56752-R
dc.relation.projectID	MINECO/BIO2017-82462-R
dc.relation.projectID	MINECO/PID2020-113062RB-100
dc.relation.projectID	FICYT/FEDER/FC-15-GRUPIN14-014
dc.relation.projectID	MINECO/FPU13/00831
dc.relation.publisherversion	http://dx.doi.org/10.1021/acschembio.2c00416
dc.rights.accessRights	open access
dc.type.hasVersion	VoR

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