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Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins
dc.contributor.author | Solé Magdalena, Antonio | |
dc.contributor.author | González Revuelta, Enrique | |
dc.contributor.author | Menéndez Díaz, Iván | |
dc.contributor.author | García Calavia, Marta | |
dc.contributor.author | Cobo Díaz, Teresa | |
dc.contributor.author | García Suárez, Olivia | |
dc.contributor.author | Pérez Piñera, Pablo | |
dc.contributor.author | Carlos Villafranca, Félix Antonio de | |
dc.contributor.author | Cobo Plana, Juan Manuel | |
dc.contributor.author | Vega Álvarez, José Antonio | |
dc.date.accessioned | 2013-01-30T09:58:51Z | |
dc.date.available | 2013-01-30T09:58:51Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Microscopy research and technique, 74(5), p. 457-463 (2011); doi:10.1002/jemt.20931 | spa |
dc.identifier.issn | 1059-910X | |
dc.identifier.uri | http://hdl.handle.net/10651/6547 | |
dc.description.abstract | Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa+C) superfamily, in particular those belonging to the acid-sensing ion channel (ASIC) family, as well as some members of the transient receptor protein (TRP) channel, function as mechanosensors or may be required for mechanosensation in a diverse range of species and cell types. Therefore, we investigated the putative mechanosensitive function of human odontoblasts using immunohistochemistry to detect ENa+C subunits (α, β, and γ) and ASIC (1, 2, 3, and 4) proteins, as well as TRPV4, in these cells. Positive and specific immunoreactivity in the odontoblast soma and/or processes was detected for all proteins studied except α-ENa+C. The intensity of immunostaining was high for β-ENa+C and ASIC2, whereas it was low for ASIC1, ASIC3, γ-ENa+C, and TRPV4, being absent for α-ENa+C and ASIC4. These results suggest that human odontoblasts in situ express proteins related to mechanosensitive channels that probably participate in the mechanisms involved in teeth sensory transmission. Microsc. Res. Tech., 2011. © 2010 Wiley-Liss, Inc. | en |
dc.format.extent | p. 457-463 | spa |
dc.language.iso | eng | |
dc.relation.ispartof | Microscopy research and technique | spa |
dc.rights | (c) Microscopy research and technique | |
dc.source | SCOPUS | spa |
dc.title | Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins | spa |
dc.type | journal article | |
dc.identifier.local | 20111955 | spa |
dc.identifier.doi | 10.1002/jemt.20931 | |
dc.relation.publisherversion | http://dx.doi.org/10.1002/jemt.20931 | spa |
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