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Indolocarbazoles glicosilados, procedimiento de obtención y usos de los mismos

Author:
Pérez Salas, AaroaUniovi authority; Sánchez Reillo, CésarUniovi authority; Fernández Braña, Alfredo JavierUniovi authority; Méndez Fernández, María del CarmenUniovi authority; Salas Fernández, José AntonioUniovi authority; Moris Varas, Francisco
Publication date:
2021-04-09
Abstract:

Glycosylated indolocarbazoles of formula (II), method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.

Glycosylated indolocarbazoles of formula (II), method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial strains. The invention also relates to the methods used to obtain the recombinant strains and the production of rebeccamycin and staurosporine derivatives. The invention also relates to bacterial strains that are of use for the production of rebeccamycin and staurosporine derivatives. Lastly, the rebeccamycin and staurosporine derivatives described herein are applicable to the field of human health, specifically for manufacturing drugs that are of use in the treatment of tumour, neurological and inflammatory diseases.

URI:
http://hdl.handle.net/10651/61897
Patrocinado por:

Universidad de Oviedo

EntreChem S.L.

Número de solicitud:
ES20170154953T
Número de la patente:
ES2818231 (T3)
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