Repository
How to publish
Resources
FAQs

Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma

Author:
Grilli, Gianluigi; Hermida Prado, Francisco JoséUniovi authority; Álvarez Fernández, M.; Allonca Campa, EvaUniovi authority; Álvarez González, Miguel; Astudillo González, María AuroraUniovi authority; Moreno Bueno, Gema; Cano, Amparo; García Pedrero, Juana MaríaUniovi authority; Rodrigo Tapia, Juan PabloUniovi authority
Subject:

Cáncer de cabeza y cuello

Publication date:
2020-11
Editorial:

Elsevier

Publisher version:
https://doi.org/10.1016/j.oraloncology.2020.105003
Citación:
Oral Oncology, 110 (2020); doi:10.1016/j.oraloncology.2020.105003
Abstract:

The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis.Our findings show the association of NOTCH pathway activation with a better prognosis in HNSCC patients, also revealing membranous NOTCH1 expression as a robust independent predictor of improved survival. Accordingly, these results suggest a tumor suppressive rather than an oncogenic role for NOTCH pathway in HNSCC.

The function of NOTCH signaling (oncogenic or oncosuppressive) remains controversial in head and neck squamous cell carcinomas (HNSCC). The purpose of this work is to investigate the role of NOTCH pathway in HNSCC prognosis.Our findings show the association of NOTCH pathway activation with a better prognosis in HNSCC patients, also revealing membranous NOTCH1 expression as a robust independent predictor of improved survival. Accordingly, these results suggest a tumor suppressive rather than an oncogenic role for NOTCH pathway in HNSCC.

URI:
http://hdl.handle.net/10651/58157
DOI:
10.1016/j.oraloncology.2020.105003
Patrocinado por:

Supported by grants from the Plan Nacional de I+D +I 2013–2016 [ISCIII (PI16/00280 and PI19/00560 to JMGP), CIBERONC (CB16/12/00390 to JPR and CB16/12/00295 to AC), Asociación Española contra el Cáncer (AECC; 2019/ INVES19001ALVA to MAF), the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155 to JPR), Fundación Bancaria Caja de Ahorros de Asturias- IUOPA and the FEDER Funding Program from the European Union.

Id. Proyecto:

ISCIII/PI16/00280

ISCIII/PI19/00560

CB16/12/00390

IDI2018/155

Collections
Files in this item
Compartir
Estadísticas de uso
Estadísticas de uso
Metadata
Show full item record