Cooperative zinc/catalytic indium system for the stereoselective sequential synthesis of (E)-1,3-dienes from carbonyl compounds

Abstract

Herein we describe a cooperative zinc/indium system for the stereoselective synthesis of highly functionalized (E)-1,3-dienes through the sequential allylation/elimination reaction of aldehydes and ketones with 1,3-dichloropropene. The main advantages of this methodology are that it has a broad substrate scope and simple procedure, requires mild conditions and is easy to operate.