Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

dc.contributor.author	Bailey, Mathew H.
dc.contributor.author	Meyerson, William U.
dc.contributor.author	Dursi, Lewis Jonathan
dc.contributor.author	López Otín, Carlos
dc.date.accessioned	2020-11-13T07:52:27Z
dc.date.available	2020-11-13T07:52:27Z
dc.date.issued	2020-12
dc.identifier.citation	Nature Communications, 11(1), p. 4748- (2020); doi:10.1038/s41467-020-18151-y
dc.identifier.issn	2041-1723
dc.identifier.uri	http://hdl.handle.net/10651/57047
dc.description.abstract	The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions.	spa
dc.format.extent	p. 4748-	spa
dc.language.iso	eng	spa
dc.publisher	Nature Research	spa
dc.relation.ispartof	Nature Communications, 11(1)	spa
dc.rights	CC Reconocimiento 4.0 Internacional
dc.rights	© The authors
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/
dc.title	Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples	spa
dc.type	journal article	spa
dc.relation.publisherversion	http://dx.doi.org/10.1038/s41467-020-18151-y	spa
dc.rights.accessRights	open access	spa
dc.type.hasVersion	VoR

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