Simple and straightforward synthesis of novel enantiopure ionic liquids via efficient enzymatic resolution of (±)-2-(1H-imidazol-1-yl)cyclohexanol
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Both enantiomers of enantiopure imidazolium ionic liquids were synthesized by a simple and straightforward procedure from (R,R)- and (S,S)-2-(1H-imidazol-1-yl)cyclohexanol derivatives obtained via lipase-catalyzed resolution. Structural properties and thermal stability of these compounds have been studied to elucidate their potential applications in asymmetric catalysis.
Both enantiomers of enantiopure imidazolium ionic liquids were synthesized by a simple and straightforward procedure from (R,R)- and (S,S)-2-(1H-imidazol-1-yl)cyclohexanol derivatives obtained via lipase-catalyzed resolution. Structural properties and thermal stability of these compounds have been studied to elucidate their potential applications in asymmetric catalysis.
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Financial support by MEC (CTQ2005-08016-003,MEC-04-CTQ-04185, MAT2006-01997, and Factoría de Cristalización Consolider Ingenio 2010) and Fundació Caixa Castelló—UJI (P1B2004-13) is acknowledged. I.A. and E.G.-V. (Ramo´n y Cajal), V.G.-F. (Juan de la Cierva Program), and E.B. (FPU) thank MEC for personal funding.
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