Lipases: Useful biocatalysts for the preparation of pharmaceuticals

Author:	Gotor Fernández, Vicente; Brieva Collado, María del Rosario; Gotor Santamaría, Vicente Miguel
Publication date:	2006
Publisher version:	https://doi.org/10.1016/j.molcatb.2006.02.010
Citación:	Journal of Molecular Catalysis B: Enzymatic, 40(3-4), p. 111-120 (2006); doi:10.1016/j.molcatb.2006.02.010
Descripción física:	p. 111-120
Abstract:	Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals. Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals.
URI:	http://hdl.handle.net/10651/54883
ISSN:	1381-1177
DOI:	10.1016/j.molcatb.2006.02.010

Repositorio Institucional de la Universidad de Oviedo