Repositorio Institucional de la Universidad de Oviedo

Lipases: Useful biocatalysts for the preparation of pharmaceuticals

Author:

Gotor Fernández, Vicente

; Brieva Collado, María del Rosario

; Gotor Santamaría, Vicente Miguel

Publication date:

2006

Publisher version:

https://doi.org/10.1016/j.molcatb.2006.02.010

Citación:

Journal of Molecular Catalysis B: Enzymatic, 40(3-4), p. 111-120 (2006); doi:10.1016/j.molcatb.2006.02.010

Descripción física:

p. 111-120

Abstract:

Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals.

Biocatalysis offers a clean and ecological way to perform chemical processes, in mild reaction conditions and with high degree of selectivity. The use of enzymes, specially lipases, in organic solvents proves an excellent methodology for the preparation of single-isomer chiral drugs. This review covers some general aspects and representative examples of the use of lipases for the enantioselective or regioselective preparation of alcohol and amine intermediates in the synthesis of pharmaceuticals.

URI:

http://hdl.handle.net/10651/54883

ISSN:

DOI:

10.1016/j.molcatb.2006.02.010

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