Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

This work was supported in part by grants from the Ministerio de Ciencia e Innovacion (Grant SAF2016-80639-P), Plan Nacional de I+D+I, Spain and the Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) (Grant 2014 SGR229), Department d'Economia I Coneixement, Catalonia, Spain, to Javier A Menendez and grants from the Czech Science Foundation (16-12816S) to Jan Stursa and Lukas Werner and the Czech Health Research Council (16-31704A) to Jiri Neuzil. Elisabet Cuyas is supported by a Sara Borrell post-doctoral contract CD15/00033 from the Ministerio de Sanidad y Consumo, Fondo de Investigacion Sanitaria (FIS), Spain, The Metabolism and Cancer laboratory is supported by an unrestricted grant from the Armangue family (Girona, Catalonia). This work is in memory of Joan Armangue who passed away after his brave fight against cancer in November 2016.