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Determinants and Prediction of Esterase Substrate Promiscuity Patterns

dc.contributor.authorMartínez Martínez, M.
dc.contributor.authorCoscolín, C.
dc.contributor.authorSantiago, G.
dc.contributor.authorMesa Salgado, Victoria María 
dc.contributor.authorPeláez Andrés, Ana Isabel 
dc.contributor.authorSánchez Martín, Jesús 
dc.date.accessioned2018-04-24T09:39:31Z
dc.date.available2018-04-24T09:39:31Z
dc.date.issued2018
dc.identifier.citationACS Chemical Biology, 13(1), p. 225-234 (2018); doi:10.1021/acschembio.7b00996
dc.identifier.issn1554-8929
dc.identifier.urihttp://hdl.handle.net/10651/46680
dc.description.sponsorshipC.C. thanks the Spanish Ministry of Economy, Industry and Competitiveness for a Ph.D. fellowship (Grant BES-2015-073829). V.M. thanks the Francisco Jose de Caldas Scholarship Program (Administrative Department of Science, Technology and Innovation, COLCIENCIAS). The authors acknowledge the members of the MAMBA, MAGICPAH, ULIXES, KILLSPILL and INMARE Consortia for their support in sample collection. David Rojo is also acknowledged for his valuable help with log P calculations. This project received funding from the European Union's Horizon 2020 research and innovation program [Blue Growth: Unlocking the potential of Seas and Oceans] under grant agreement no. 634486 (project acronym INMARE). This research was also supported by the European Community Projects MAGICPAH (FP7-KBBE-2009-245226), ULIXES (FP7-KBBE-2010-266473), and KILLSPILL (FP7-KBBE-2012-312139) and grants BIO2011-25012, PCIN-2014-107, BIO2014-54494-R, and CTQ2016-79138-R from the Spanish Ministry of Economy, Industry and Competitiveness. The present investigation was also funded by the Spanish Ministry of Economy, Industry and Competitiveness within the ERA NET IB2, grant no. ERA-IB-14-030 (MetaCat), the UK Biotechnology and Biological Sciences Research Council (BBSRC), grant no. BB/M029085/1, and the German Research Foundation (FOR1296). R.B. and P.N.G. acknowledge the support of the Supercomputing Wales project, which is part-funded by the European Regional Development Fund (ERDF) via the Welsh Government. O.V.G. and P.N.G. acknowledge the support of the Centre of Environmental Biotechnology Project funded by the European Regional Development Fund (ERDF) through the Welsh Government. A.Y. and A.S. gratefully acknowledge funding from Genome Canada (2009-OGI-ABC-1405) and the NSERC Strategic Network grant IBN. A.I.P. was supported by the Counseling of Economy and Employment of the Principality of Asturias, Spain (Grant FC-15-GRUPIN14-107). V.G. acknowledges the joint BSC-CRG-IRB Research Program in Computational Biology. The authors gratefully acknowledge financial support provided by the European Regional Development Fund (ERDF).
dc.description.statementofresponsibilityMartínez-Martínez, M., Coscolín, C., Santiago, G., Chow, J., Stogios, P.J., Bargiela, R., Gertler, C., Navarro-Fernández, J., Bollinger, A., Thies, S., Méndez-García, C., Popovic, A., Brown, G., Chernikova, T.N., García-Moyano, A., Bjerga, G.E.K., Pérez-García, P., Hai, T., Del Pozo, M.V., Stokke, R., Steen, I.H., Cui, H., Xu, X., Nocek, B.P., Alcaide, M., Distaso, M., Mesa, V., Peláez, A.I., Sánchez, J., Buchholz, P.C.F., Pleiss, J., Fernández-Guerra, A., Glöckner, F.O., Golyshina, O.V., Yakimov, M.M., Savchenko, A., Jaeger, K.-E., Yakunin, A.F., Streit, W.R., Golyshin, P.N., Guallar, V., Ferrer, M.
dc.format.extentp. 225-234
dc.language.isoeng
dc.relation.ispartofACS Chemical Biology, 13
dc.rights© 2017 American Chemical Society
dc.sourceScopus
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85040583025&doi=10.1021%2facschembio.7b00996&partnerID=40&md5=9dc3f1de18db055cb5b8d3093b08baa1
dc.titleDeterminants and Prediction of Esterase Substrate Promiscuity Patterns
dc.typejournal article
dc.identifier.doi10.1021/acschembio.7b00996
dc.relation.projectIDMINECO/BES-2015-073829
dc.relation.projectIDMINECO/BIO2014-54494-R
dc.relation.projectIDH2020/634486
dc.relation.projectIDCE/FP7-KBBE-2010-266473
dc.relation.publisherversionhttp://dx.doi.org/10.1021/acschembio.7b00996
dc.rights.accessRightsopen access


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