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The results would not have been achieved without the selfless collaboration of the study participants ("INMA families"). The authors are grateful to Richard Davies for editorial assistance. This study was funded by grants from the Spanish Ministry of Health-Instituto de Salud Carlos III (Red INMA G03/176; FIS PI041436, PI042018, PI06/0867, PI081151, PI09/00090, PI09/02311, PI11/0610, PI13/02187, PI13/02406, PI13/02429, PI13/1944, PI13/2032, PI14/0891, PI14/1687, PI16/1288; CB06/02/0041; and Miguel Servet-FEDER funds MS15/0025, MS16/00085, and MS13/00054); European Union (FP7-ENV-2011 DENAMIC cod 282,957); Conselleria de Sanitat, Generalitat Valenciana (FISABIO UGP 15-230); Generalitat de Catalunya-CIRIT 1999SGR 00241; Fundacio La marato de TV3 (090430); Department of Health of the Basque Government (2005111093, 2009111069, 2013111089 and 2015111065), Provincial Government of Gipuzkoa (DFG06/002, DFG08/001 and DFG15/221). The funders had no role in the study design, data collection, or analysis, decision to publish, or preparation of the manuscript. The authors have no relevant affiliation or financial involvement with any organization or entity with a financial interest or conflict with the subject matter discussed in the manuscript.