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Double-chained cationic surfactant modification of SU-8/Pyrex® microchips for electrochemical sensing of carboxylic ferrocene after reverse electrophoresis

dc.contributor.authorAlonso Bartolomé, Rebeca 
dc.contributor.authorGonzález López, Andrea 
dc.contributor.authorFernández Abedul, María Teresa
dc.identifier.citationSensors and Actuators B: Chemical, 255, p. 490–497 (2018); doi:10.1016/j.snb.2017.08.012
dc.description.abstractThis paper describes the effect ofthe modification of microchip microchannels with two different cationic surfactants on the electrochemical behavior of ferrocene carboxylic acid (FCA), common redoxprobe in bioanalysis. Cetyltrimethylammonium bromide (CTAB), a single-chain surfactant, and didecyldimethylammonium bromide (DDAB), double-chained, were evaluated. The purpose was to obtain a reversal of the electroosmotic flow for allowing precise determination of FCA, an anionic probe that is employed in electrochemical bioassays. Although this was possible in both cases, modification of the microchannel with a high concentration of CTAB produced a differentiation between the free CTAB fraction and the CTAB-combined FCA. DDAB is presented as a good alternative for this modification because this doublechained cationic surfactant forms a more stable quasi-permanent coating on the microchannel surface, avoiding these surfactant-probe interactions. Linear relationship was found between the analytical signal and the concentration of FCA (evaluated between 10 and 150 M) for a modification with 0.1 mM of DDABspa
dc.description.sponsorshipThis work has been supported by MICINN under projects CTQ2011-25814 and by the Asturias Government with funds from PCTI 2006–2009, cofunded with FEDER funds (Programa Operativo FEDER del Principado de Asturias 2007–2013) under project FC-11-PC10-30
dc.format.extentp. 490–497spa
dc.relation.ispartofSensors and Actuators B: Chemical, 255spa
dc.rights© 2017 Elsevier B.V
dc.rightsCC Reconocimiento - No comercial - Sin obras derivadas 4.0 Internacional
dc.subjectFerrocene carboxylic acidspa
dc.subjectMicrochip electrophoresisspa
dc.subjectElectrochemical detectionspa
dc.subjectDDAB surfactantspa
dc.titleDouble-chained cationic surfactant modification of SU-8/Pyrex® microchips for electrochemical sensing of carboxylic ferrocene after reverse electrophoresisspa
dc.relation.projectIDPCTI 2006–2009

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