Ketopremithramycins and ketomithramycins; four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces Argillaceus; reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway
Fecha de publicación:
2002
Editorial:
American Chemical Society
Versión del editor:
Citación:
Journal of the American Chemical Society, 124(8), p. 1606-1614 (2002); doi:10.1021/ja0105156
Descripción física:
p. 1606-1614
DOI:
Patrocinado por:
This work was supported by grants of the South Carolina Commission of Higher Education (2000−2001), the U.S. Department of Defense, and the National Institutes of Health (R01CA91901) to J.R., and by the Spanish Ministry of Education and Science to J.A.S. through the “Plan Nacional en Biotecnologia” (R01CA91901). Drs. William Cotham and Michael Walla, Department of Chemistry and Biochemistry, University of South Carolina, are acknowledged for recording the FAB mass spectra.
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