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María Dolores Cima-Cabal and this work were supported by ASTUR-PHARMA, Oviedo, Spain. We wish to thank the nursing staff and the laboratory technicians of the Hospital Central de Asturias for their collaboration. The authors are indebted to the Laboratorio de Proteómica, Centro Nacional de Biotecnología, CSIC, Madrid, Spain, for performing the mass spectrometry analyses. We are also grateful to David H. Wallace (member of the Council of Science Editors and the European Association of Science Editors) for the English language correction of the manuscript.