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Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus

Author:
Prado Álvarez, LauraUniovi authority; Lombó Brugos, FelipeUniovi authority; Fernández Braña, Alfredo JavierUniovi authority; Méndez Fernández, María del CarmenUniovi authority; Rohr, Jürgen; Salas Fernández, José AntonioUniovi authority
Publication date:
1999
Publisher version:
http://dx.doi.org/10.1007/s004380050960
Citación:
Molecular and General Genetics, 261, 2, p. 216-225 (1999); doi:10.1007/s004380050960
Descripción física:
p. 216-225
URI:
http://hdl.handle.net/10651/40169
ISSN:
0026-8925
DOI:
10.1007/s004380050960
Patrocinado por:

Work on this project was supported by grants from the Plan Nacional en Biotecnologia to J.A.S. (BIO94-0037; BIO97-0771), the European Union to J.A.S. and J.R. (BIOTECH programme BIO4-CT96-0068) and the Medical University of South Carolina to J.R. We would like to thank the Lilly Co. for cosmid pKC505 and Pfizer Co. for the kind gift of mithramycin.

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