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New insights on the development of Streptomyces and their relationships with secondary metabolite production

dc.contributor.authorYagüe Menéndez, Paula 
dc.contributor.authorLópez García, María Teresa (Bio) 
dc.contributor.authorRioseras de Bustos, Beatriz 
dc.contributor.authorSánchez Martín, Jesús 
dc.contributor.authorManteca Fernández, Ángel 
dc.date.accessioned2015-10-06T07:40:58Z
dc.date.available2015-10-06T07:40:58Z
dc.date.issued2012
dc.identifier.citationCurrent trends in microbiology, 8, p. 65-73 (2012)
dc.identifier.issn0972-7736
dc.identifier.urihttp://hdl.handle.net/10651/33649
dc.description.abstractStreptomycetes are very important industrial bacteria, which produce two thirds of all clinically relevant secondary metabolites. Furthermore, they produce large numbers of eukaryotic cell differentiation and apoptosis inducers. Streptomyces is a mycelial soil bacterium characterized by a complex developmental cycle that includes programmed cell death (PCD) phenomena and sporulation in solid cultures. Industrial fermentations are usually performed in liquid cultures, conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. Recently, novel aspects concerning differentiation during the presporulation phases were described in solid and liquid cultures, as well as in natural soils. In this review, we analyze the status of knowledge regarding the above-named aspects of Streptomyces differentiation and their relationships with secondary metabolite production.eng
dc.description.sponsorshipAuthors wish to thank the European Research Council for economic support (ERC Starting Grant; Strpdifferentiation 280304) and Subdirección General de Proyectos de Investigación (DGI MICINN, Spain, grant BIO2010-16303).
dc.format.extentp. 65-73spa
dc.language.isoengspa
dc.publisherResearch Trends
dc.relation.ispartofCurrent trends in microbiology, 8spa
dc.subjectStreptomyceseng
dc.subjectDifferentiationeng
dc.subjectsporulationeng
dc.subjectAntibioticeng
dc.titleNew insights on the development of Streptomyces and their relationships with secondary metabolite productioneng
dc.typeinfo:eu-repo/semantics/article
dc.type.dcmitextspa
dc.relation.projectIDStrp-differentiation 280304
dc.relation.projectIDMICINN/BIO/2010-16303


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