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Development of a chemoenzymatic strategy for the synthesis of optically active and orthogonally protected polyamines

dc.contributor.authorBusto García, Benjamín Eduardo 
dc.contributor.authorGotor Fernández, Vicente 
dc.contributor.authorMontejo Bernardo, José Manuel 
dc.contributor.authorGarcía-Granda, Santiago 
dc.contributor.authorGotor Santamaría, Vicente Miguel 
dc.date.accessioned2013-01-30T10:21:02Z
dc.date.available2013-01-30T10:21:02Z
dc.date.issued2009
dc.identifier.citationTetrahedron, 65(40), P. 8393-8401 (2009); doi:10.1016/j.tet.2009.08.001spa
dc.identifier.issn0040-4020
dc.identifier.urihttp://hdl.handle.net/10651/10818
dc.description.abstractThe chemical preparation and stereoselective enzymatic desymmetrization of a series of prochiral 2-substituted-1,3-propanediamines have been carried out using Pseudomonas cepacia lipase as biocatalyst. Syntheses of novel optically active orthogonally protected di- or triamines have been achieved for the first time with different grade of enantiodiscrimination depending on the C-2 substitution of the propane-1,3-diamine fragment. Final monoselective deprotection reactions of (S)-3-allyl-2-tert-butyl-1-(9-fluorenylmethyl)propane-1,2,3-triyltriscarbamate have allowed us to obtain a panel of novel enantiomerically enriched disubstituted triamines, compounds of difficult access by conventional synthetic methods.spa
dc.format.extentp. 8393-8401spa
dc.language.isoeng
dc.relation.ispartofTetrahedronspa
dc.rights(c) Tetrahedron
dc.sourceSCOPUSspa
dc.source.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-69249185638&partnerID=40
dc.titleDevelopment of a chemoenzymatic strategy for the synthesis of optically active and orthogonally protected polyaminesspa
dc.typeinfo:eu-repo/semantics/article
dc.identifier.local20090255spa
dc.identifier.doi10.1016/j.tet.2009.08.001
dc.type.dcmitextspa
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.tet.2009.08.001spa


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