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Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents

dc.contributor.authorAlvarado Narváez, Mario
dc.contributor.authorGoya Laza, Pilar
dc.contributor.authorMacías González, Manuel
dc.contributor.authorPavón, Francisco Javier
dc.contributor.authorSerrano, Antonia
dc.contributor.authorJagerovic, Nadine
dc.contributor.authorElguero Bertolini, José
dc.contributor.authorGutiérrez Rodríguez, Ángel 
dc.contributor.authorGarcía-Granda, Santiago 
dc.contributor.authorSuardíaz, Margarita
dc.contributor.authorRodríguez de Fonseca, Fernando
dc.date.accessioned2013-01-30T10:17:21Z
dc.date.available2013-01-30T10:17:21Z
dc.date.issued2008
dc.identifier.citationBioorganic & Medicinal Chemistry, 16(23), P. 10098-10105 (2008); doi:10.1016/j.bmc.2008.10.023spa
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10651/10148
dc.description.abstractSearching for new antiobesity agents, a new series of fatty acid amide derivatives of 1,5-diarylpyrazole have been synthesized as dual peroxisome proliferator activated receptor alpha (PPARα)/cannabinoid receptor ligands. The compounds have been evaluated in vivo and in vitro as PPARα activators and as cannabinoids in two tests of the mouse tetrad. In vivo, food intake studies have been performed with all the compounds. No significant cannabinoid activity has been found but some compounds behaved as potent PPARα activators. Several compounds showed anorexigenic properties reducing food intake in rats.spa
dc.format.extentp. 10098-10105spa
dc.language.isoeng
dc.relation.ispartofBioorganic & Medicinal Chemistryspa
dc.rights(c) Bioorganic & Medicinal Chemistry
dc.sourceWOKspa
dc.subjectPyrazole; Oleylamide; Pparα; Dmlsspa
dc.titleAntiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agentsspa
dc.typejournal article
dc.identifier.local450spa
dc.identifier.doi10.1016/j.bmc.2008.10.023
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bmc.2008.10.023spa


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