Halonitro compounds: a master key in drug industry

Abstract

Gem-halonitro functionalized compounds have significant importance in the synthesis of bioactive compounds. In this regard, many β-arylnitroethenes have used as versatile intermediates in the synthesis of farmacological relevant moieties, such as cyclopropanes, amides, nitroalkanes and functionalized alkenes. The objetive of the present work is to investigate the relevance of 1-bromonitroalkenes as synthetic intermediates. In this regard, a simple 1-bromonitroalkene will be synthetized in the laboratory and applied to the stereoselective preparation of 1,2-arylnitroalkenes by the means of a transition metal-catalyzed cross-coupling reaction.