Mostrar el registro sencillo del ítem
Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application.
dc.contributor.author | Del Río Ibiste, N. | |
dc.contributor.author | Granda Díaz, Rocío | |
dc.contributor.author | Rodrigo Tapia, Juan Pablo | |
dc.contributor.author | Menendez, S. T. | |
dc.contributor.author | García Pedrero, Juana María | |
dc.date.accessioned | 2021-03-16T10:58:04Z | |
dc.date.available | 2021-03-16T10:58:04Z | |
dc.date.issued | 2020-08 | |
dc.identifier.citation | Del-Río-Ibisate N., Granda-Díaz R., Rodrigo J.P., Menéndez S.T. y García-Pedrero J.M. (2020) Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application. En Reviews of Physiology, Biochemistry and Pharmacology. Berlin, Heidelberg : Springer | |
dc.identifier.uri | http://hdl.handle.net/10651/58156 | |
dc.description.abstract | This chapter intends to comprehensively and critically review the current state-of-art ion channel dysregulation specifically focusing on head and neck cancers and to formulate the major challenges and research needs to translate this knowledge into clinical application. Based on current reported data, various voltage-gated potassium (Kv) channels (i.e. Kv3.4, Kv10.1 and Kv11.1) have been found frequently aberrantly expressed in HNSCC as well as precancerous lesions and are highlighted as clinically and biologically relevant features in both early stages of tumourigenesis and late stages of disease progression. More importantly, they also emerge as promising candidates as cancer risk markers, tumour markers and potential anti-proliferative and anti-metastatic targets for therapeutic interventions; however, the oncogenic properties seem to be independent of their ion-conducting function. | spa |
dc.description.sponsorship | This work was supported by grants from the Plan Nacional de I+D+I 2013-2016 from ISCIII (PI16/00280 and PI19/00560) and CIBERONC (CB16/12/00390), the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155) and the FEDER Funding Program from the European Union | spa |
dc.language.iso | eng | spa |
dc.publisher | Springer Nature | spa |
dc.relation.ispartof | Reviews of Physiology, Biochemistry and Pharmacology | spa |
dc.rights | © Springer Nature Switzerland AG 2020 | |
dc.subject | Cáncer de cabeza y cuello | spa |
dc.title | Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application. | spa |
dc.type | journal article | spa |
dc.identifier.doi | 10.1007/112_2020_38 | |
dc.relation.projectID | ISCIII/PI16/00280 | |
dc.relation.projectID | ISCIII/PI19/00560 | |
dc.relation.projectID | CB16/12/00390 | |
dc.relation.projectID | IDI2018/155 | |
dc.relation.publisherversion | https://doi.org/10.1007/112_2020_38 |
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
Capítulos de libros [5888]